Mederic Mouterde
PhD
Présentation
Mon travail de PhD se focalise sur l'adaptation des humains modernes à différents environnements chimiques (incluant l'environnement alimentaire) par le biais d'un groupe de gènes de grand intérêt médicale : les gènes impliqués dans la métabolisation des médicaments (ADME). Cette approche implique la collection et la génération de données phénotypiques et génomiques à partir de populations humaines diverses nouvellement échantillonées.
Publications
Mouterde, M., Daali, Y., Rollason, V., Čížková, M., Mulugeta, A., Al Balushi, K. A., Fakis, G., Constantinidis, T. C., Al-Thihli, K., Černá, M., Makonnen, E., Boukouvala, S., Al-Yahyaee, S., Yimer, G., Černý, V., Desmeules, J., & Poloni, E. S. (2022). Joint analysis of phenotypic and genomic diversity sheds light on the evolution of xenobiotic metabolism in humans. Genome Biology and Evolution, 14(12), evac167.
Gloor, Y., Matthey, A., Sobo, K., Mouterde, M., Kosek, E., Pickering, G., Poloni, E. S., Cedraschi, C., Ehret, G., & Desmeules, J. A. (2022). Uncovering a Genetic Polymorphism Located in Huntingtin Associated Protein 1 in Modulation of Central Pain Sensitization Signaling Pathways. Frontiers in Neuroscience, 16.
Kulichová, I., Mouterde, M., Mokhtar, M. G., Diallo, I., Tříska, P., Diallo, Y. M., Hofmanová, Z., Poloni, E. S., & Černý, V. (2022). Demographic history was a formative mechanism of the genetic structure for the taste receptor TAS2R16 in human populations inhabiting Africa's Sahel/Savannah Belt. American Journal of Biological Anthropology, 177(3), 540-555.
Rollason, V.*, Mouterde, M.*, Daali, Y., Čížková, M., Priehodová, E., Kulichová, I., Posová, H., Petanová, J., Mulugeta, A., Makonnen, E., Davidson, R., Al-Balushi, K., Al-Thihli, K., Cerná, M., Al-Yahyaee, S., Černý, V., Yimer, G., Poloni, E. S., & Desmeules, J. (2020). Safety of the Geneva cocktail, a cytochrome P450 and P-glycoprotein phenotyping cocktail, in healthy volunteers from three different geographic origins. Drug safety, 43, 1181-1189. * equally contributed
Vangenot, C., Gagneux, P., de Groot, N. G., Baumeyer, A., Mouterde, M., Crouau-Roy, B., Darlu, P., Sanchez-Mazas, A., Sabbagh, A., & Poloni, E. S. (2019). Humans and chimpanzees display opposite patterns of diversity in arylamine N-acetyltransferase genes. G3: Genes, Genomes, Genetics, 9(7), 2199-2224.
de Villemereuil, P., Mouterde, M., Gaggiotti, O. E., & Till‐Bottraud, I. (2018). Patterns of phenotypic plasticity and local adaptation in the wide elevation range of the alpine plant Arabis alpina. Journal of Ecology, 106(5), 1952-1971.
de Villemereuil, P., Gaggiotti, O. E., Mouterde, M., & Till-Bottraud, I. (2016). Common garden experiments in the genomic era: new perspectives and opportunities. Heredity, 116(3), 249-254.
