contenu | table des matières | déclaration d'accessibilité'

Unité d'anthropologie

L'Unité d'anthropologie fait partie du
Département de génétique et évolution
de l'Université de Genève.

Bienvenue à l'Unité d'anthropologie

L'Unité d'anthropologie est, depuis 2011, la nouvelle structure émanant de l’ex-Département d’anthropologie de l’Université de Genève, et aujourd’hui rattachée au Département de génétique et évolution (GENEV) dirigé par le Professeur Denis Duboule. Composée de deux laboratoires, le Laboratoire d'anthropologie, génétique et peuplements (AGP) et le Laboratoire d’archéologie et peuplement de l'Afrique (APA), elle regroupe des chercheurs et enseignants spécialisés dans les domaines de l’anthropologie biologique, de la génétique et l’évolution des populations humaines, de la préhistoire, de l'archéologie africaine, de l'ethnoarchéologie, de l’ethnologie et de l’histoire de l’anthropologie.

L’Unité d’anthropologie participe à plusieurs filières de formation : le bachelor en biologie, le bachelor en biologie orientation préhistoire, le master en biologie, le master en archéologie préhistorique, le doctorat ès sciences mention biologie, le doctorat ès sciences mention archéologie préhistorique, et le doctorat ès sciences mention anthropologie. Elle collabore aussi au programme doctoral "Ecologie et biologie évolutive" de la CUSO et coordonne le programme Erasmus "Archéologie et peuplement".

L’Unité d’anthropologie, se trouve au Quai Ernest-Ansermet 30.


HLA cover page

HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection

The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present larger repertories of peptides than homozygotes.

Afficher les actualités plus anciennes

Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa

Dietary changes associated to shifts in subsistence strategies during human evolution may have induced new selective pressures on phenotypes, as currently held for lactase persistence. Similar hypotheses exist for arylamine N-acetyltransferase 2 (NAT2) mediated acetylation capacity, a well-known pharmacogenetic trait with wide inter-individual variation explained by polymorphisms in the NAT2 gene.

HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B polymorphisms

Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions—the B and F pockets—of the peptide-binding region (PBR). HLA alleles within the same supertype are expected to be functionally similar, while those from different supertypes are expected to be functionally distinct, presenting different sets of peptides. In this study, we applied the supertype classification to the HLA-A and HLA-B data of 55 worldwide populations in order to investigate the effect of natural selection on supertype rather than allelic variation at these loci.

A New HLA Map of Europe: Regional Genetic Variation and Its Implication for Peopling History, Disease-Association Studies and Tissue Transplantation

HLA genes are highly polymorphic in human populations as a result of diversifying selection related to their immune function. However, HLA geographic variation worldwide suggests that demographic factors also shaped their evolution. We here analyzed in detail HLA genetic variation in Europe in order to identify signatures of migration history and/or natural selection.

Genetic Diversity in European Populations: Evolutionary Evidence and Medical Implications

Explaining the genetic diversity of past and present European populations. Although it is the continent with the lowest genomic diversity, Europe embraces a significant degree of variation, shaped by complex demographic events and locus-specific selective factors linked to environmental conditions. The European genetic diversity observed today has also important clinical and epidemiological implications. Different questions related to these topics are addressed in this special topic issue of eight excellent papers written by specialized European teams. The papers document the remarkable progress achieved in the last years in exploring human genomic diversity, both in past and present populations, in reconstructing complex scenarios of European peopling history using sophisticated data analyses and computer simulations, in identifying signatures of adaptive selection in milk digestion- and immune-related genes, and in applying this knowledge to crucial health issues, from tissue transplantation to disease associations.

Dr Anne Mayor

Early social complexity in the Dogon Country (Mali) as evidenced by a new chronology of funerary practices

The emergence and evolution of social complexity remains a major topic in African later prehistory. This paper aims to examine this question in the Dogon Country in Mali by reassessing the chronocultural sequence of Toloy-Tellem-Dogon that was defined 40 years ago. Our discovery of two new sites on the Bandiagara Escarpment with coiled clay tombs (Dourou-Boro and Yawa-vaches), the systematic dating of these structures, the re-analysis of similar buildings in Pégué, as well as the establishment of a typol- ogy of architectural techniques, led us to propose a continuous chronocultural evolution for these struc- tures, now considered to be primary burials and not granaries, over about 1800 years. Detailed study of the ceramics also indicates the evolution of local traditions, progressively integrating new elements fol- lowing many contacts with neighboring regions during the 1st millennium AD. Finally, the chemical anal- ysis of the glass beads discovered in Dourou-Boro shows that these societies were using beads made in the Middle East at least from the last quarter of the 1st millennium AD on. The new data presented in this article highlight, on one hand, the originality, antiquity, and longevity of burial practices indicating a strong local cultural identity, and, on the other hand, the participation of pre-Dogon populations (long reputed for being isolated from the outside world) in broader African socioeconomic dynamics.

Logo 7 Cooperation

A Europe-wide Strategy to enhance Transplantation of highly sensitized patients on basis of Acceptable HLA Mismatches

Alicia Sanchez-Mazas is the partner for the University of Geneva of the FP7-Health program EUROSTAM, which has been supported by a € 2.6 million grant. The main objective of the three year project is to determine the feasibility and advantage of implementing a Europe-wide acceptable mismatch program to facilitate transplantation of highly sensitized patients all over Europe. Sanchez-Mazas’ group is involved as an expert of HLA molecular diversity in human populations, with a main participation to the definition of a new epitope-based matching programme.

Archéologie en Pays Dogon, peuplement humain, présent et passé, en Afrique occidentale

Que peuvent nous apprendre les fouilles d’Ounjougou au Mali ? Une histoire bien différente de celle que nous connaissons, ou du moins, que nous supposons. Homme de terrain et théoricien de l’archéologie, Eric Huysecom, œuvre depuis 25 ans à comprendre l'histoire du peuplement humain de l’Afrique. Il vient de découvrir, que, bien avant l’Europe, les populations d’Afrique de l’Ouest, invente le Néolithique et, avec celui-ci, un cortège de nouveautés. C’était il y a 11400 ans…

“Human neutral genetic variation and forensic STR data”

The forensic genetics field is generating extensive population data on polymorphism of short tandem repeats (STR) markers in globally distributed samples. In this study we explored and quantified the informative power of these datasets to address issues related to human evolution and diversity, by using two online resources: an allele frequency dataset representing 141 populations summing up to almost 26 thousand individuals; a genotype dataset consisting of 42 populations and more than 11 thousand individuals.

Alicia Sanchez-Mazas

“Faire avancer l'anthropologie pour que les mentalités évoluent”

“Alicia Sanchez-Mazas mène dans son laboratoire de l’Université de Genève des études sur la diversité génétique humaine. Son objectif : mieux comprendre l’histoire du peuplement et briser certaines conceptions dépassées sur l’espèce humaine”.

Portrait du Professeure Alicia Sanchez-Mazas dans l'édition de novembre de la revue La Recherche.

Centres de recrutements

“The Heterogeneous HLA Genetic Makeup of the Swiss Population”

This study aims at investigating the HLA molecular variation across Switzerland in order to determine possible regional differences, which would be highly relevant to several purposes: optimizing donor recruitment strategies in hematopoietic stem cell transplantation (HSCT), providing reliable reference data in HLA and disease association studies, and understanding the population genetic background(s) of this culturally heterogeneous country. More… HLA molecular data of more than 20,000 HSCT donors from 9–13 recruitment centers of the whole country were analyzed. Allele and haplotype frequencies were estimated by using new computer tools adapted to the heterogeneity and ambiguity of the data. Non-parametric and resampling statistical tests were performed to assess Hardy-Weinberg equilibrium, selective neutrality and linkage disequilibrium among different loci, both in each recruitment center and in the whole national registry. Genetic variation was explored through genetic distance and hierarchical analysis of variance taking into account both geographic and linguistic subdivisions in Switzerland. The results indicate a heterogeneous genetic makeup of the Swiss population: first, allele frequencies estimated on the whole national registry strongly deviate from Hardy-Weinberg equilibrium, by contrast with the results obtained for individual centers; second, a pronounced differentiation is observed for Ticino, Graubünden, and, to a lesser extent, Wallis, suggesting that the Alps represent(ed) a barrier to gene flow; finally, although cultural (linguistic) boundaries do not represent a main genetic differentiation factor in Switzerland, the genetic relatedness between population from south-eastern Switzerland and Italy agrees with historical and linguistic data. Overall, this study justifies the maintenance of a decentralized donor recruitment structure in Switzerland allowing increasing the genetic diversity of the national—and hence global—donor registry. It also indicates that HLA data of local donor recruitment centers can be used as reference data in both epidemiological and population genetic studies focusing on the genetic history of present European populations.

Lire le communiqué de presse

Phil. Trans. R. Soc. B March 19, 2012; 367 (1990) Cover

“Distinct evolutionary strategies of human leucocyte antigen loci in pathogen-rich environments”

Human leucocyte antigen (HLA) loci have a complex evolution where both stochastic (e.g. genetic drift) and deterministic (natural selection) forces are involved. Owing to their extraordinary level of polymorphism, HLA genes are useful markers for reconstructing human settlement history. However, HLA variation often deviates significantly from neutral expectations towards an excess of genetic diversity. More… Because HLA molecules play a crucial role in immunity, this observation is generally explained by pathogen-driven-balancing selection (PDBS). In this study, we investigate the PDBS model by analysing HLA allelic diversity on a large database of 535 populations in relation to pathogen richness. Our results confirm that geographical distances are excellent predictors of HLA genetic differentiation worldwide. We also find a significant positive correlation between genetic diversity and pathogen richness at two HLA class I loci (HLA-A and -B), as predicted by PDBS, and a significant negative correlation at one HLA class II locus (HLA-DQB1). Although these effects are weak, as shown by a loss of significance when populations submitted to rapid genetic drift are removed from the analysis, the inverse relationship between genetic diversity and pathogen richness at different loci indicates that HLA genes have adopted distinct evolutionary strategies to provide immune protection in pathogen-rich environments.

Université de Genève
Dépt. de Génétique & Evolution
Unité d'anthropologie
Quai Ernest-Ansermet 30
1205 Genève
Tél. +41 22 379 69 67
Fax. +41 22 379 31 94